Manchester City are waiting to learn the extent of an injury suffered by David Silva during the early stages of Spain's 1-1 draw against France.
Silva was replaced after just 10 minutes of Tuesday's 2014 World Cup qualifier after pulling up with a muscle injury in his right leg.
He was replaced by Santi Cazorla and reports in Spain suggest that playmaker Silva is facing at least two weeks on the sidelines.
The World Cup holders also lost Alvaro Arbeloa to a muscle problem early in the second half and Spain coach Vicente del Bosque admitted the injuries affected his plans.
"The injuries were an immediate misfortune because it prevented us from managing the changes," Del Bosque said.
"There haven't been any muscular injuries in my four years here and so to have two I am sorry about."
If Silva is ruled out for a fortnight, he would miss City's Premier League games against West Brom and Swansea, plus next week's UEFA Champions League tie away to Ajax.