The Republic of Ireland's injury problems have worsened ahead of Friday's World Cup qualifier with Germany after Sean St Ledger and Glenn Whelan were ruled out.
Leicester defender St Ledger and Stoke midfielder Whelan have withdrawn after undergoing scans on hamstring injuries and the pair will join Aston Villa centre-back Richard Dunne and Wolves striker Kevin Doyle on the sidelines.
Sunderland midfielder James McClean will miss the Germany match with a hip flexor strain and is a doubt for Tuesday's trip to the Faroe Islands.
A spokesman said: "The results of James McClean's scan this morning in Sunderland showed a grade one hip flexor strain which will certainly rule him out for the Germany match and may exclude him for the Faroe Islands.
"McClean will remain at his club to receive treatment.
"Further to scans earlier in the day, both Sean St Ledger and Glenn Whelan have been confirmed as out of both matches against Germany and the Faroe Islands."
Giovanni Trapattoni admits he cannot afford to take a gamble on a player's fitness as he attempts to pick up a result at the Aviva Stadium.
"I can't speak as doctor - I am manager. But muscle injuries need time, time, time.
"You don't want a player to play 10, 15, 20, 70 minutes and then have a hamstring injury again. I don't want to take risks.
"It's very important, this game. We also need to make our three substitutions to change the game, not because of injuries from before."
The absence of Dunne and St Ledger means that John O'Shea could be moved into central defence, while James McCarthy, David Meyler and Keith Fahey are candidates to replace Whelan in midfield.