Sir Alex Ferguson has left midfield trio Paul Scholes, Ryan Giggs and Michael Carrick out Manchester United's squad for their UEFA Champions League clash with CFR Cluj.
The Red Devils, who suffered a shock 3-2 home defeat at the hands of Tottenham in the Premier League on Saturday evening, have named a number of youngsters in their 21-man party.
Ferguson watched his side triumph 1-0 over Galatasaray in their opening Group H encounter and will be keen to build on that success in Romania on Tuesday evening, with their opponents currently top of the standings after a 2-0 success away to Braga.
There was some good news for Ferguson with centre-back Jonny Evans available despite taking a knock in the closing stages against Spurs, with Nemanja Vidic, Chris Smalling and Phil Jones all remaining on the sidelines through injury.
Evans and Rio Ferdinand are expected to be paired in the centre of defence, while Michael Keane and Scott Wootton have been included as cover.
Antonio Valencia (ankle) and Ashley Young (knee) will not feature, meaning Darren Fletcher, Jesse Lingard, Nick Powell and Ryan Tunnicliffe are among Ferguson's midfield options.
Man Utd squad: De Gea, Lindegaard; Buttner, Evans, Evra, Ferdinand, M.Keane, Rafael, Wootton; Anderson, Cleverley, Fletcher, Lingard, Nani, Powell, Tunnicliffe; Hernandez, Kagawa, Rooney, van Persie, Welbeck.