West Brom midfielder Zoltan Gera was substituted due to injury while captaining Hungary against Andorra on Friday.
The 33-year-old felt pain in his Achilles during the interval after picking up a knock in the first half and was withdrawn.
Hungary coach Sandor Egervari has confirmed that Gera is not expected to feature against Holland on Tuesday.
Gera's side were not troubled by his absence as they marched to a convincing 5-0 win with Bolton's Adam Bogdan keeping a clean sheet.
But the Baggies man will be hoping his injury is not too serious after missing much of the last campaign with a cruciate knee ligament problem suffered in November 2011.