Sky Sports understands Wolves goalkeeper Wayne Hennessey has been ruled out for the rest of the season after scans revealed he had suffered a torn cruciate ligament.
The Molineux No.1 sustained the knee injury during Saturday's 0-0 draw at Sunderland and was sent for an MRI examination which confirmed the club's worst fears.
Terry Connor's side are already staring relegation in the face as they currently sit eight points adrift of safety with only four games remaining and with a significantly inferior goal difference.
And they must now face their remaining fixtures without the Wales international shot-stopper, who had racked up 58 consecutive Premier League appearances, a run which stretches back to November 2010.
With the 25-year-old sidelined, former Swansea goalkeeper Dorus de Vries is poised to make his debut in Sunday's game against Manchester City.
Hennessey now faces a lengthy road back to full fitness over the next three or four months and faces a battle to be fit for the start of next season.