Ligue 1 outfit Nice have announced that midfielder Emerse Fae has been advised to quit top-level football for health reasons.
The 28-year-old Ivory Coast international was sidelined with phlebitis, an inflammation of a vein caused by a blood clot, for three months in 2009 and again in March 2011.
He returned to the Nice squad in September of last year, but a relapse in October has led medical staff to call on him to hang up his boots.
The news has come as a blow to the player and his club, with both having held out hope that he would soon be able to continue with his career.
A statement released on Nice's official website read: "A feeling of sadness has fallen over the red and black family.
"The panel of experts who evaluated the case of Emerse Fae have not authorised him to continue his football career at the highest level."
Fae, who was under contract until June, joined Nice from Reading in 2008 having previously represented Nantes in France.