Sylvain Marveaux has lost his race to be fit for Newcastle's trip to table-topping Manchester City this weekend.
The influential former Rennes midfielder has made a big impact at the club since opting against agreeing a move to Liverpool in favour of the North East side in the summer.
The 25-year-old had hoped to shake off a groin injury he picked up against Everton in time to travel to the Etihad Stadium but there are fears he could be out for at least two weeks
The news came as a blow to Magpies boss Alan Pardew who could also be without Gabriel Obertan and Cheick Tiote, but it was softened by the return of Shola Ameobi to full fitness.
Pardew told the Newcastle Chronicle: "Marveaux is definitely out. Shola will be involved as he's back to fitness, so that is good news for us.
"We are still sweating on Cheick and Obertan."