Samir Nasri has pulled out of France's friendlies against the United States and Belgium due to injury, while Florent Malouda is also a doubt.
Another Premier League player, Yohan Cabaye, is touch-and-go for the USA match ahead of a scan, while Marseille's Loic Remy is a concern for Les Bleus boss Laurent Blanc.
Manchester City midfielder Nasri has been carrying a knee injury since the UEFA Champions League win over Villarreal and at the same time has also been forced to seek emergency dental treatment in Paris.
He told French television: "I have a problem in my knee since the Villarreal match." He added: "It's an old issue which is resurfacing."
France boss Blanc had told L'Equipe earlier on Tuesday: "Nasri has big tendinitis in the patella tendon. He also had a dental problem that forced him to Paris to see a dentist urgently."
Chelsea midfielder Malouda has a thigh complaint and striker Remy is a doubt as he is struggling with an adductor injury.
The France squad are gathered at their training headquarters in Clairefontaine to prepare for the friendlies against the USA and Belgium and Blanc revealed the doubts over his key men.
Blanc is likely to wait until Wednesday morning before naming his squad to face the USA and is not ruling out making changes ahead of the game against Belgium next Tuesday.
"We'll see who's missed out in the first game and could recover for the second," he added. "Based on that, we'll see if I recall one or two players."