Villarreal's preparations for Wednesday's clash with Manchester City have been dealt another untimely blow by injury news concerning Cristian Zapata.
The Spanish outfit are due to face City in the latest round of UEFA Champions League fixtures, but will do so without a number of key men.
The Primera Liga club announced on Monday that Colombia international Zapata has been added to their ever-lengthening injury list.
The defender has sprained ligaments in his right knee and is expected to be sidelined for up to five weeks.
The loss of Zapata comes just 24 hours after it was revealed that Cani, Marco Ruben and Marcos Senna all suffered problems in Saturday's 2-0 victory over Rayo Vallecano.
Cani will be out for around six weeks with a knee sprain of his own, Ruben has an adductor injury and Senna will be rested after feeling a twinge in his hamstring.
Javier Camunas is also doubtful for European duty due to a lower leg injury and star strikers Giuseppe Rossi and Nilmar will definitely miss out.
Italy international Rossi suffered a serious knee injury in a recent league fixture against Real Madrid and could be out for up to six months.
Nilmar, meanwhile, is still working his way back to fitness after undergoing an operation to remove a knee cyst at the start of October.
Coach Juan Carls Garrido now finds himself down to the bare bones ahead of a game against City that Villarreal desperately need to win.
The Yellow Submarines have lost their opening three fixtures in Group A and sit four points adrift at the bottom of the table.