Scunthorpe boss Alan Knill was left to rue some poor finishing by his side in their 1-0 Johnstone's Paint Trophy defeat by Oldham.
Striker Shefki Kuqi got the only goal of the game after 27 minutes to give the Latics their first cup win in any competition since August 2008.
"It's always disappointing when you get a defeat, especially at home," said Knill.
"We had so many chances, particularly in the second half, that we could have won two games.
"But it's all about putting the ball in the back of the net and that is something we could not manage to do."