Italy will be without defender Domenico Criscito and striker Giampaolo Pazzini for their two remaining Euro 2012 qualifiers.
Zenit Saint Petersburg's Criscito will be missing with a groin strain while Inter Milan's Pazzini will take no part due to an ankle problem.
Pazzini was already doubtful to feature against Serbia and Northern Ireland with medical staff now confirming he will not recover in time.
Italy head coach Cesare Prandelli could be missing a third player with Palermo defender Federico Balzaretti also touch and go due to injury.
However, the Azzurri will not be pressing the panic button as Italy have already booked their place in Euro 2012 as Group C winners.
Italy travel to Belgrade on Friday and host Northern Ireland at Pescara next Tuesday.