James Collins, Joe Ledley and Danny Collins have been forced to pull out of Wales' upcoming Euro 2012 qualifiers.
Gary Speed's side are set to face Switzerland on Friday before bringing the curtain down on their Group G campaign against Bulgaria next Tuesday.
Aston Villa defender James Collins will play no part as he is currently nursing a knee problem.
Celtic midfielder Ledley is also missing with a groin complaint, while Danny Collins, who is currently on loan at Ipswich from Stoke, is carrying a similar ailment.
Speed has moved to cover the loss of the experienced trio by drafting in two replacements.
Crystal Palace's Jonathan Williams and Bristol City's Lewin Nyatanga have been added to the squad.
Wales are unable to qualify for next summer's European Championship but will be keen to end their qualification campaign on a high.