Theo Walcott, Laurent Koscielny and Gervinho have been ruled out of Arsenal's UEFA Champions League clash with Olympiakos.
England winger Walcott picked up a knee injury late on during Arsenal's 3-0 win over Bolton on Saturday and he missed training on Tuesday.
Ivory Coast star Gervinho will also miss the visit of Olympiakos along with defender Koscielny meaning Arsene Wenger will have to shuffle his pack.
Koscielny has an ankle problem sustained in a challenge with Bolton's Nigel Reo-Coker, while Gervinho is struggling with a muscle strain.
Wenger is hopeful all three will recover in time to be fit for this weekend's North London derby with Tottenham at White Hart Lane.
"Koscielny, Gervinho and Walcott are not fit," said Wenger.
"All three have a chance for the weekend. Walcott could make the derby. He has more than a 50-50 chance."