Sky Sports sources understand that Roque Santa Cruz is to undergo a medical at Real Betis on Saturday.
The Manchester City striker has been linked with a number of clubs this summer, with it clear that he has no future at Eastlands.
The Paraguayan has slowly slipped down the pecking order at City since signing from Blackburn in 2009.
Having found himself out of favour, Roque Santa Cruz returned to Ewood Park on loan last season.
He was unable to earn a permanent move to Rovers but is expected to be offloaded by City before the transfer window slams shut.
Betis have been touted as his most likely destination, and they are closing in on a deal.
The Primera Liga new boys are looking to piece together a squad that is capable of keeping them in the Spanish top flight and believe Santa Cruz could provide the goals to see them safe.