Barcelona defender Gerard Pique has torn a calf muscle in training and will be out of action for three weeks.
The news that Pique is sidelined is the last thing head coach Pep Guardiola needs with fellow defender Carlos Puyol also out injured.
Pique will now sit out Friday's Super Cup clash with Europa League winners Porto in Monaco.
Guardiola can still turn to Andreu Fontas, Eric Abidal, Javier Mascherano and Sergio Busquets, or the Barca B squad, for the two centre-half spots.
The Spain international will also miss his country's upcoming games against Chile and Liechtenstein.