Brighton kicked off their new era at the Amex Stadium with a 3-2 defeat against Tottenham Hotspur.
The Seagulls made the perfect start with Ashley Barnes scoring the first goal at the 22,500 all-seater stadium after 11 minutes.
Defenders Younes Kaboul and Vedran Corluka turned the game around for Spurs before Kazenga Lua Lua equalised in the second half.
But Jake Livermore ensured it was a winless start for Brighton at their new home.
England left-back Leighton Baines fired home a trademark free-kick as Everton won 2-1 at recently relegated Birmingham City.
Last season's top scorer Louis Saha doubled the Toffees' advantage before Adam Rooney netted for the hosts.
Lloyd Dyer scored a late consolation as Leicester City lost 2-1 at home in their glamour friendly with Real Madrid, who had earlier scored through Jose Callejon and Karim Benzema.
New signing Ben Foster kept a clean sheet as West Brom nicked a late 1-0 win at Bristol City.
Substitute Craig Dawson grabbed the decisive goal by planting home a header from Graham Dorrans' corner.
Burnley ended their pre-season campaign with a well-deserved win over a new-look Sunderland side.
Striker Jay Rodriguez rifled home a first-half penalty for a 1-0 triumph at Turf Moor.
There were no goals at Hillsborough where Stoke City were held by League One hosts Sheffield Wednesday.
Chances were rare with Stoke, who fielded two different teams in either half, coming the closet when Diego Arismendi's late strike cannoned back off the post.
Bolton boasted four new summer signings as they eased to a 3-1 success at Newport County.
The Welsh side took the lead before Ivan Klasnic's brace and an own goal swung the game in favour of the Trotters, who handed starts to Nigel Reo-Coker, Darren Pratley, Chris Eagles and Tyrone Mears.
Matt Taylor and Freddie Sears were on target as West Ham United beat Real Zaragoza 2-0 at Upton Park.
Lee Bowyer's first goal in Ipswich colours could not prevent his new team going down 2-1 against Wolves.
Late goals from Stephen Hunt and Sylvan Ebanks-Blake cancelled out the one-time England international's opener at Portman Road.
Seven goals were shared between Millwall and Charlton in an entertaining London derby for Alan Dunne's testimonial.
But it was hosts Millwall who edged the contest with strikes from James Henry, John Marquis (2) and Hameur Bouazza, with Bradley Wright-Phillips (2) and Johnnie Jackson replying.
A late goal from Radoslaw Majewski handed Nottingham Forest a hard-earned victory over Lincoln City at Sincil Bank.
The Poland international struck 11 minutes from time following good work from Andy Reid.
Barnsley capped a fine pre-season with a thumping 5-0 win at Scunthorpe.
Trialist Ricardo Vaz Te opened the scoring before recent signing Craig Davies (2), Kyel Reid and Nathan Doyle completed the rout.
Bradford City went down 3-1 against Carlisle at Valley Parade, while Torquay flew to a comfortable 6-2 win at Truro.
Barnet and MK Dons shared the spoils in a 1-1 draw and Stevenage won 2-1 at Dagenham and Redbridge.
Brentford secured a 2-1 success at Aldershot, York triumphed by the same scoreline when they entertained Hartlepool, as did Northampton against Wycombe.