Jack Collison could return from a 14-month injury lay-off to play some role in West Ham's crunch clash at Manchester City on Sunday.
The Wales midfielder was a key performer for the Hammers last season but sustained a serious knee injury while on international duty in March 2010 and has not featured since.
However, Collison has made steady progress in his rehabilitation and could make his comeback at Eastlands provided he comes through Thursday's reserve fixture against Wolves unscathed.
The 22-year-old's return would provide a timely boost for Hammers boss Avram Grant, who has a number of injury problems in midfield as the East Londoners battle against relegation.
Scott Parker has missed the last two games with an Achilles complaint while Gary O'Neil is out for the season with a serious ankle injury.
The club should know the results of tests on Mark Noble's stomach injury on Thursday.
The central midfielder had to come off in the second half of Saturday's 3-0 defeat to Chelsea after feeling discomfort in his stomach after shooting at goal.