Tottenham Hotspur's club captain Ledley King is likely to miss the rest of the season due to an ongoing groin injury.
King has not made a first-team appearance for Spurs since October and underwent surgery on the problem in February.
However, the defender is likely to require another operation and his continued absence has left manager Harry Redknapp short of options.
Jonathan Woodgate suffered a calf injury in a friendly against Barnet in midweek, while Younes Kaboul and William Gallas are also struggling for fitness.
Redknapp fears he will have only two fit centre-halves available for Saturday's game at Wigan Athletic and next week's UEFA Champions League trip to Real Madrid.
With the biggest match in the club's history against a star-studded Real team just around the corner, Redknapp admits his defensive troubles are a big concern.
"We started the year with six central defenders here. Now we have two," Redknapp told Sky Sports News.
"We have lost Ledley King, it looks like he will have to have an operation that will finish his season.
"Jonathan Woodgate was making good progress but got a calf injury in a friendly against Barnet and Younes Kaboul is still out with a thigh strain.
"William Gallas has been for a scan on his knee today. He struggled at the weekend and we are now down to having just Michael Dawson and Sebastien Bassong."