Seamus Coleman has been forced to pull out of the Republic of Ireland squad to face Macedonia with an ankle injury.
The versatile 22-year-old picked up the problem whilst playing for Everton at the weekend and has been unable to train over the past few days.
He was assessed on Thursday afternoon and the decision has now been taken to send him back to Merseyside for treatment.
Coleman's withdrawal is the latest blow to hit Republic manager Giovanni Trapattoni, after Newcastle striker Leon Best was also ruled out of the crucial Euro 2012 qualifier.
Sean St Ledger, a regular in Trapattoni's first-choice defence, has also not trained since picking up a knee injury in Tuesday morning's session, and his fitness is being closely monitored.
Republic are currently joint second in Group B, two points adrift of leaders Russia and level with Armenia and Slovakia.