AC Milan midfielder Andrea Pirlo will miss both legs of his side's UEFA Champions League last-16 tie against Tottenham.
The influential schemer has been ruled out for six weeks after suffering knee ligament damage.
Pirlo, 31, had been due to return to the Milan side to face Parma on Saturday after three weeks out with a hamstring injury, but he picked up the new problem in training on Friday.
A Milan statement read: "Medical tests carried out yesterday confirmed that midfielder Andrea Pirlo had suffered a second grade strain of the medial collateral ligament in his right knee.
"The player's expected recovery time is six weeks."
Pirlo was making a return from a thigh injury when he picked up the hamstring problem against Bari.