Leon Best and Liam Lawrence have withdrawn from the Republic of Ireland squad for next week's Carling Nations Cup clash with Wales.
Newcastle striker Best has pulled out with a hamstring injury he sustained in his side's incredible 4-4 draw with Arsenal.
Best's injury is another blow for Newcastle after Shola Ameobi picked up a fractured cheekbone earlier this week just two days after selling Andy Carroll to Liverpool.
Bristol City striker Andy Keogh has been drafted in as a replacement by Republic of Ireland boss Giovanni Trapattoni.
Portsmouth midfielder Liam Lawrence has also withdrawn because of a calf problem he sustained in his side's 1-1 draw with Derby on Saturday.