On-loan striker Cody McDonald netted a hat-trick for Gillingham to help sink Stockport 5-1.
The 24-year-old Norwich star was the Hatters' worst nightmare as he put his side ahead in the 32nd minute to record his ninth of the campaign.
The visitors made it 2-0 when Andy Barcham scored six minutes after the interval before McDonald bagged another.
Stockport had a chance to battle back when Ishmel Demontagnac scored with 20 minutes to go, however goals from Curtis Weston and McDonald's third and his 11th of the campaign overall ensured there was no way back for the home side.
League-leaders Chesterfield had a scare when they looked to be cruising thanks to Danny Whitaker scoring from the spot and a cool finish from Deane Smalley. However Craig Easton scoring a stunning effort with over half an hour to go.
Ryan Hall brought down Drew Talbot in the box which saw Whitaker score another from the spot and looked to have secured the points for the Spireites.
However, the Shrimpers nearly turned the game on its head when Barry Corr netted a penalty after a push in the area. But the away side managed to hang on for the win and moved five points ahead of second-placed Rotherham who play on Tuesday.
Crewe ended Wycombe's five-game winning run with an emphatic 3-0 victory at Gresty Road.
Clayton Donaldson put the game to bed with a quick-fire brace in the 71st and 72nd minute before Shaun Miller ended all hopes of a Wycombe comeback.
Morecambe travelled to Shrewsbury and came away with a 3-1 win. Goals came from a Dean Holden own goal, a tidy finish from James Spencer and 24-year-old Laurence Wilson converted from the spot after a foul on Mark Duffy.
Shane Cansdell-Sherriff's 67th minute goal failed to inspire a comeback as the Shrews slipped up and the Shrimps recorded a much-needed win.
Barnet came from behind to kill off a tough Bradford City side after Luke Oliver had given the Bantams the lead on the stroke of half-time.
But the Bees went on the onslaught despite an appalling away record when City's Rob Kiernan put into his own net and strikes from Anwar Uddin and Ricky Holmes ensured the points for a 3-1 victory.
Accrington and Oxford secured wins against Bury and Aldershot respectively.
Joe Jacobson scored the only goal of the game at the Crown Ground as 18th-placed Stanley dispatched a fifth-placed Bury side.
Tom Craddock was the hero for the Us as his 85th minute goal proved to be the winner.
A minute before Luke Guttridge had equalised for the Shots to cancel out Anthony Charles' eighth-minute own goal, however Chris Wilder's men hung on for the three points.
Northampton and Cheltenham shared the spoils at Sixfields with Billy McKay's strike for the Cobblers and a Wesley Thomas finish for the visitors.