Roberto Martinez says Chris Kirkland's prognosis is positive, but expects Tom Cleverley to be out for a month.
The Wigan manager saw his side further hit by injuries during their 1-1 draw with Bolton on Wednesday night, with Kirkland and Cleverley the latest names on an already lengthy casualty list.
The Latics are already missing James McCarthy, Victor Moses, Emmerson Boyce and Franco di Santo due to various problems, while Charles N'Zogbia will be absent for Saturday's FA Cup clash with Hull City due to suspension.
Martinez is not sure on how long goalkeeper Kirkland will be out after he was told he would have to spend the next 24 hours in hospital as a precaution.
"The first report is good," said Martinez of the keeper, who was carried off the pitch on a stretcher after being knocked out following a clash with Trotters striker Johan Elmander.
"Chris is going to be in hospital for 24 hours as a precaution but the first report was quite positive."
While the Spaniard is optimistic over Kirkland, he was disappointed to learn Cleverley could be out for a month after pulling his hamstring in the opening minutes at the Reebok Stadium.
"To lose Tom, who has been a really inspirational player, and you are limited," he added.
"We think he'll be out for three to four weeks, but he's only 21 and is very fit, so he should be back quicker than most other players."