Peter Odemwingie and Chris Brunt are struggling to be fit for West Brom's derby clash with Aston Villa at the weekend.
Leading scorer Odemwingie has been unable to train this week with a groin problem suffered during last Sunday's 3-1 win over Newcastle, in which he netted a brace.
Brunt, who has had a groin injury in recent weeks, is also a doubt for Saturday's clash at Villa Park as the key midfielder has been unable to play a full part in training.
Baggies boss Roberto Di Matteo confirmed: "We have some problems. Odemwingie hasn't trained this week yet. He has got a groin problem.
"If he manages to train on Friday, we have a chance. We have to wait and see how he is going to be.
"Chris Brunt had to miss some training sessions so we just have to manage him and Peter and hope they will be available for Saturday."
While Albion are five points clear of struggling Villa after back-to-back wins over Everton and Newcastle, Di Matteo is keeping grounded.
He said: "I don't think it counts for very much (being above Villa) at this stage of the season.
"We are delighted with the points we have (22) by the middle of December.
"We are just going to try and add some more as soon as we can. That's our focus.
"You can sense from the fans how important the derby is. From the start of the season, there are a few fixtures that the supporters remind you of.
"But it is not just the local derbies you need to do well in. You need to do well in the other games as well otherwise it won't be enough."