Manchester United will be without Rio Ferdinand and Nemanja Vidic when they face Rangers on Wednesday.
The centre-half pairing were put through their paces in training on Tuesday, but both have been left out of Sir Alex Ferguson's squad for the UEFA Champions League trip to Ibrox.
The United boss has opted to rest the pair with the fixtures coming thick and fast at the moment.
The Red Devils face Blackburn in a tough Premier League contest on Saturday before taking on West Ham in the Carling Cup quarter-finals next Tuesday.
With a point all that is required from the midweek visit to Glasgow to book their place in the Champions League knockout stages, United feel they are in a position to shuffle their pack.
That means Chris Smalling and Jonny Evans are likely to deputise for Ferdinand and Vidic in the Battle of Britain clash with Rangers.
Darren Fletcher is another of those to have been overlooked by Ferguson in Europe, with the midfielder having taken in domestic and international duties over recent weeks.
Gary Neville and Darron Gibson were the other notable absentees from training on Tuesday, missing out on Ferguson's last-minute preparations.
Ryan Giggs was involved and is expected to play some part at Ibrox, while Wayne Rooney is in line to make his first start since penning a new long-term contract at Old Trafford.