Michael Carrick could make his Manchester United comeback against Valencia, although Gary Neville and Paul Scholes have joined the list of absentees.
Former Tottenham midfielder Carrick has not started a game since the Community Shield but has flown with the rest of United's squad for their UEFA Champions League match on Wednesday.
Manager Sir Alex Ferguson reported last Friday that Carrick had returned to training after he had an injection to try to ease the discomfort from a niggling Achilles problem last month.
The news of Carrick's return comes as a welcome boost to United, who are also without experienced duo Neville and Scholes in addition to the losses of Ryan Giggs (hamstring) and Wayne Rooney (ankle).
As yet it is not known why Scholes and Neville were absent from United's travelling party to Spain and it can only be assumed the pair are being rested or are being protected from minor injuries ahead of their weekend clash with Sunderland.
United's squad is also boosted by the inclusion of summer signing Bebe and England defender Rio Ferdinand, who missed the club's 2-2 Premier League draw with Bolton on Sunday.
Bebe was a surprise signing by Ferguson during the transfer window and he made his debut off the bench for the club in last week's 5-2 Carling Cup over Scunthorpe United at Glanford Park and looked promising.