Fernando Torres, Pepe Reina and Andres Iniesta have all been recalled to the Spain squad by Vicente Del Bosque.
The trio missed the friendly with Mexico earlier in the month with injuries but are now set to feature in the Euro 2012 qualifier against Liechtenstein on 3rd September and a friendly against Argentina in Buenos Aires four days later.
Spain will be looking to retain the European Championship in two years time, and, if they do, it will mean three major international competitions in three attempts following their World Cup triumph this summer.
The World Cup winners who do not make the 21-man squad are Real Madrid defender Raul Albiol who is injured, while Athletic Bilbao midfielder Javi
Martinez is on Under-21 duty and Valencia forward Juan Manuel Mata has not been selected.
Villarreal's Santi Cazorla, the only man included who missed out on the South Africa showpiece this summer, retains his place after being called up for the Mexico clash.
If Spain are going to make the tournament in Poland and Ukraine, they will have to qualify from a group containing Scotland, the Czech Republic and Lithuania as well as Liechtenstein.
Spain squad in full:
Iker Casillas (Real Madrid), Victor Valdes (Barcelona), Jose Reina (Liverpool); Alvaro Arbeloa (Real Madrid), Sergio Ramos (Real Madrid), Carles Puyol (Barcelona), Gerard Pique (Barcelona), Carlos Marchena (Villarreal), Joan Capdevila (Villarreal); Xabi Alonso (Real Madrid), Sergio Busquets (Barcelona), Xavi (Barcelona), Santi Cazorla (Villarreal), Cesc Fabregas (Arsenal), Andres Iniesta (Barcelona), Pedro (Barcelona), Jesus Navas (Sevilla), David Silva (Manchester City); David Villa (Barcelona), Fernando Llorente (Athletic Bilbao), Fernando Torres (Liverpool).