Carlo Ancelotti has announced that Ramires will not be involved at Wigan but should make his debut against Stoke.
The Brazilian midfielder joined Chelsea from Benfica last week in a big-money deal but is not yet ready to be in contention.
Blues supporters are likely to get a first glimpse of Ramires in action the following Saturday when Stoke travel to Stamford Bridge.
Ancelotti has few injury concerns to key players ahead of the clash with the Latics and revealed that Jose Bosingwa will soon be back in training following a long lay-off due to a knee problem.
"Ramires came back this morning, he will train today, and will not be involved tomorrow," the Chelsea manager said on the club's official website.
"Next week he will be ready to play against Stoke and he will be involved in the match.
"(Branislav) Ivanovic had a little problem in his stomach and is fit and ready to play tomorrow.
"We are without (Jose) Bosingwa, he will start to train with the team next week and maybe needs again two or three weeks to play.
"(Jeffrey) Bruma will have surgery this morning for a hernia, and (Gael) Kakuta has a problem on his back.
"The other players are in good condition. (Frank) Lampard had a problem before the match against West Bromwich on his ankle, but trained well, recovered well and is fit."
Chelsea suffered a surprise defeat at the DW Stadium last season before taking their revenge on the final day of the campaign with an 8-0 home victory that clinched the title.
The Blues then continued their prolific goalscoring form by beating West Brom 6-0 on the opening day of this term, but Ancelotti is not expecting an easy match.
He said: "I am sure it will be a different game tomorrow (to West Brom), the last game at Wigan we lost 3-1 and for this reason I think we have to prepare well for this game, above all mentally.
"I will be happy if we can win just 1-0. It is important to have a clean sheet, it is important to score when possible but this is not football, to win 6-0 or 7-0 cannot happen every day. It is important to win, to play well, and if possible to score.
"We have to pay attention, they started bad, lost at home against Blackpool and they want to be strong, to have power tomorrow, to do a different match. We have to pay attention because they have quality and skills in front."