Carlos Cuellar and James Collins have handed Aston Villa a selection dilemma ahead of the new season.
The defensive duo have both been ruled out of Villa's Premier League opener against West Ham on Saturday.
Right-back Cuellar has failed to shake off a hamstring complaint in time to face the Hammers, while central defender Collins is nursing a calf problem.
Both men were regular members of the Villa back four last term, helping to form part of a resolute unit that conceded just 39 goals in 38 top flight games.
Their absence will undoubtedly be felt, but the Villans are hoping Curtis Davies (knee) and Gabriel Agbonlahor (hamstring) will be in contention.
Caretaker coach Kevin MacDonald, who will oversee the weekend's events in the wake of Martin O'Neill's resignation, admits Cuellar and Collins will be big losses, but is confident he has enough quality at his disposal to make a bright start.
"Carlos is still not outside running because of the hamstring injury he picked up," he said.
"He's getting there but he won't be ready for Saturday.
"James will return to training later this week. He won't be available for the weekend though.
"We have injuries but you have to deal with them. Let's see what we can do with what we've got."
MacDonald added: "Curtis and Gabby are both joining in. How far down the line they are, I'll have to assess over the next couple of days.
"You always get little niggles, with the hard grind of pre-season, but I am confident whatever side we put out will compete with West Ham on Saturday."