Joachim Low has said it is unlikely that Cacau will feature in Germany's World Cup quarter-final clash with Argentina.
The Stuttgart striker missed out against England with an abdominal strain and has not figured in training since.
Although not completely ruling him out of Saturday's crunch tie, Low said: "We have to be realistic.
"I don't think he will be able to play tomorrow," he added, whilst confirming additional injury concerns.
A race against time
Lukas Podolski missed training on Thursday with a thigh strain and will face a race against time to be fit.
"He has had physio today in our hotel," said Low on Friday. "The plan is for him to take part in training this evening.
"If he fails his fitness test, we will have to come up with another solution."
Marko Marin and Marcell Jansen are on standby should their services be required for Germany who are bidding to overhaul Argentina as they did at the same stage in the competition four years ago.
Low has also confirmed that Mesut Ozil will resume training on Friday having enjoyed a small rest in proceedings.
"Last year, Ozil played in the European Under-21 championships so he has had a long season," he said.
"He lost energy in the weeks leading up to the tournament and then worked very hard against England, so I gave him a day off to recharge his batteries."