Uruguay defender Diego Godin has been ruled out of the World Cup quarter-final clash with Ghana on Friday as coach Oscar Tabarez named his starting XI.
Godin suffered a thigh injury during the 2-1 victory over South Korea in Saturday's second round triumph and was forced out of the action at the interval.
Tabarez will again turn to Mauricio Victorino to deputise in Godin's absence, after he stepped off the bench and performed well against the Asian outfit.
Tabarez is unsure if Godin will even be fit for a place on the bench, but admitted: "We still have 48 hours.
"He is not fully recovered. He is not in the team because in my opinion he is not 100 per cent fit."
The coach of the South American outfit will make one further change to his starting XI, with Alvaro Fernandez coming in for Alvaro Pereira in midfield.
Fernando Muslera, who has been beaten just once in four games, starts in goal behind a back four of Maxi Pereira, Diego Lugano, Victorino and Jorge Fucile.
Diego Perez, Egidio Arevalo and Fernandez make up the midfield with Luis Suarez, Diego Forlan and Edinson Cavani operating as an attacking trio.
Uruguay, who lifted the World Cup in 1930 and 1950, finished fourth in the 1970 showpiece but failed to qualify for five of the nine tournaments since then.
They are favourites to progress to the last four of the tournament in Friday's clash at Soccer City in Johannesburg where either Brazil or Holland will await.
Tabarez, nicknamed 'The Master' from his previous career as a schoolteacher, added: "We are calm. But we know the important thing is the match, not how we feel today."