Germany boss Joachim Low has major doubts over injured pair Bastian Schweinsteiger and Jerome Boateng ahead of Sunday's England clash.
Midfielder Schweinsteiger picked up a thigh muscle injury in the final Group D match against Ghana, while defender Boateng is also doubtful following his calf muscle injury in the same game.
Low said there are major doubts about the pair, who missed training on Friday and will only face the Three Lions if 100 per cent fit.
The German boss said: "Bastian is the heart of the team, the motor in our midfield. Of course it would be a big disadvantage if he could not play.
"There is a huge question mark for both players. Their muscle problems have not yet healed and they will not train today.
"It is very questionable whether they will be 100 per cent fit because we need players who are fully fit for this game.
"With a 90 per cent fitness it is just not possible."
Low said 20-year-old midfielder Toni Kroos, who came on as a substitute for Schweinsteiger late in the Ghana match, could replace him from the start.
"I can well imagine that Toni Kroos could come in," he said.
"He came on against Ghana and immediately found his way into the match. He was not nervous at all."
Left-back Holger Badstuber, who had started in Germany's two other Group D encounters against Australia and Serbia, is expected to replace Boateng.