Catania striker Jorge Martinez has been left out of coach Oscar Tabarez's 23-man squad for the World Cup in South Africa.
Martinez has recently been linked with a move to Lazio, but will not get the chance to showcase his talent on a global stage after being dropped by Tabarez.
From his provisional 26-man squad, Tabarez has also decided to leave midfield duo Jorge Rodriguez and Alvaro Gonzalez out of his plans.
Rodriguez and Gonzalez had been unexpected inclusions in the preliminary party but have been unable to force their way into the final squad.
Meanwhile, Tabarez has expressed his satisfaction with how his team's preparations for the tournament have been progressing.
Tabarez said: "We have no injury concerns and everyone looks in good shape.
"Certain players that may have arrived with less playing time like (Juventus defender Martin) Caceres still have two weeks to improve their condition.
"We will begin working on Thursday focusing on the tactics and concepts before our opening game against France.
"Our aim is to do a good job at the World Cup and I have it very clear in my mind what we need to do."
Uruguay face France in their opening game of Group A on 11th June before fixtures against hosts South Africa and Mexico.
Goalkeepers: Fernando Muslera (Lazio), Juan-Guillermo Castillo (Cali), Martin Silva (Defensor Sporting)
Defenders: Diego Lugano (Fenerbahce), Diego Godin (Villarreal), Andres Scotti (Colo Colo), Jorge Fucile (Porto), Martin Caceres (Juventus), Mauricio Victorino (Universidad de Chile), Maximiliano Pereira (Benfica)
Midfielders: Walter Gargano (Napoli), Egidio Arevalo-Rios (Penarol), Sebastian Eguren (AIK Stockholm), Diego Perez (Monaco), Alvaro Pereira (Porto), Alvaro Fernandez (Universidad de Chile), Ignacio Gonzalez (Valencia), Nicolas Lodeiro (Ajax)
Strikers: Sebastian Fernandez (Banfield), Luis Suarez (Ajax), Diego Forlan (Atletico Madrid), Sebastian Abreu (Botafogo), Edinson Cavani (Palermo).