Stephen Ward has undergone an exploratory knee operation and will sit out the rest of the season as a result.
The Wolves midfielder has now gone under the knife twice this season in an effort to clear up an ongoing problem.
He first required surgery back in September but has been complaining of discomfort in the same area of his knee over recent weeks and it was decided to send him back for further treatment.
Ward will now miss Wolves' final two fixtures of the 2009/10 campaign and is unlikely to be in a position to join a Republic of Ireland training camp in June after being handed a first call-up by his country.
While everyone at Molineux feels for the 25-year-old, as he struggles to shake off the complaint, it is hoped he will be back to full fitness and raring to go in time for pre-season training.
Wolves boss Mick McCarthy said: "Wardy has had an operation. It's something that needed to be done as he's been struggling with the problem for a while."
Ward added: "This has been troubling me all season and has got to be done.
"There was talk about maybe delaying the operation so I could join up with Ireland, but the specialist said to carry on could make it worse.
"I've also got to be back for pre-season and so the extra couple of weeks before the end of the season will help.
"It's disappointing not to be joining up with Ireland but hopefully I'll get another chance when I'm fit again.
"There's no point risking any further damage. The swelling's still quite bad so they need to go in and clean it up."