Kevin Blackwell admits he may be forced into the loan market after seeing Henri Camara pick up a knock.
The Sheffield United striker suffered a groin strain during Saturday's 1-1 draw at Doncaster.
He becomes the latest in a long line of casualties to have undermined the Blades' promotion push this season.
His absence leaves United short on attacking options heading into the final throws of the 2009/10 campaign, and Blackwell admits that is an issue he may need to address before the loan window slams shut.
"We don't know the severity of Henri's groin injury, but as soon as it went he came off," said Blackwell.
"It leaves us threadbare in terms of strikers and I'm going to have to consider trying to get a loan in for Wednesday night.
"Certainly no Championship club is likely to help us out, so it seems likely that we will probably focus our efforts on young Premier League players.
"If we don't succeed though, whoever comes in will do a good job because our strength is in our resilience - our players, loans or not, all want to do their best for Sheffield United."