Harry Redknapp has admitted that Liverpool will miss Fernando Torres and Steven Gerrard but he is still expecting a difficult game.
Tottenham will be aiming to boost their UEFA Champions League hopes when they travel to Anfield on Wednesday to take on fellow European hopefuls Liverpool.
The Reds will be without their two best players due to injury and Redknapp is looking for his side to take advantage.
"I'd be lying if I stood here and said that the absence of Gerrard and Torres won't matter," said the Spurs manager.
"Of course, they are two world-class players, and they will miss them.
"But they have a strong squad. I have never been there and had an easy game. It is a difficult place to go."
Tottenham have injury concerns of their own as Aaron Lennon is set to miss the match with a groin problem.
However, Redknapp has received better news on Ledley King, who sat out the weekend draw with Hull City because of a bad knee.
"He had another scan on his sore knee, but the scan showed up okay," Redknapp explained.
Redknapp must decide whether to recall Peter Crouch to his starting line-up in midweek after the giant striker came on for Robbie Keane against Hull and posed more of a threat.
"It is a good run we're in, so let's hope we can keep it going at Liverpool. It will be a different game there," he commented.
"When Crouch came on against Hull, and not being disrespectful to Robbie, we suddenly looked [more dangerous].
"They put so many bodies in there and it was hard to play through them.
"When Crouch came on we could miss them out and drop balls up to him and he won headers and we were getting shots on goal."