Andy Johnson has suffered another setback in his recovery from a niggling groin problem.
The Fulham striker had been hoping to make his return to action in Wednesday's Europa League clash with FC Basle.
However, the England international was not among the Cottagers' travelling party heading to Switzerland on Tuesday.
Roy Hodgson has now confirmed that Johnson, who underwent exploratory surgery at the end of November, has seen his rehabilitation dealt a blow, but has hinted that he could be ready to face Manchester United at Craven Cottage on Saturday.
"We were hoping to have Andy Johnson with us but it is not possible," said the Fulham boss.
"He trained yesterday (Monday) but felt a problem and we had to take him out of our plans.
"We are probably being too optimistic. He was so anxious himself to get back into the fray and we sometimes go along with it.
"It was a movement that caused him a sharp pain. We took the decision not to risk him and to leave him back for treatment and possibly training back home.
"I am hoping it was to do with the scar tissue following his recent operation rather than a major problem.
"If he is pain free he will be fit enough and he will play a part in the game (against Manchester United). We will see."