Kolo Toure and Emmanuel Adebayor are hoping their absence will not affect Manchester City's Carling Cup dreams.
The duo are set to head off to the Africa Cup of Nations in January, ruling them out of domestic action at a crucial stage of the season.
As well as missing a number of Premier League fixtures, they will also be forced to sit out a highly-anticipated Carling Cup semi-final date with arch-rivals Manchester United.
That contest will represent the first time in 28 years that City have reached the last four of a major competition.
Toure, who is expected to be drafted into the Ivory Coast squad in the New Year, admits he is devastated to be missing out on such an historic occasion.
"It's incredibly bad timing," the combative centre-half said in the Daily Star.
"This club has waited a long time to be in a semi-final and to not be part of it is really difficult.
"But we have the players to beat United and I believe in my heart we're going to do it."
Togo frontman Adebayor is also hoping that his Eastlands team-mates can do the business, as he is desperate to erase the memories of a Carling Cup final defeat with Arsenal in 2007.
"I've played in a final, but I was on the losing side, for Arsenal against Chelsea," he said.
"I would love to come back from Africa with an opportunity to be in another Wembley final - and get a winners' medal this time."