USA internationals Jonathan Spector and Jay DeMerit insist they are looking forward to locking horns with England at next summer's World Cup.
America have been drawn in Group C alongside the Three Lions, as well as Algeria and Slovenia.
England have already been installed as firm favourites to progress to the knockout stages as group winners, but know they cannot afford to be complacent.
The USA proved their credentials by finishing as runners-up at the 2009 Confederations Cup, seeing off European Champions Spain along the way, while Algeria and Slovenia are likely to provide stubborn resistance.
West Ham defender Spector is adamant England will not have things all their own way in South Africa, claiming America are more than capable of springing an upset.
He said: "The US doesn't get a lot of respect on the world football stage but we're used to it and it's to our benefit. We proved that by beating Spain.
"If people want to underestimate us, that's fine. England will be favourites but we're looking forward to the challenge."
Watford stopper DeMerit is also relishing the prospect of going head-to-head with England's galaxy of stars and insists America have enough talent at their disposal to trouble Fabio Capello's side.
"It makes it extra special that we are playing England," he said.
"It's not extra pressure, it's fun. Most of our guys have played at that level before so there will be no superhero worshipping from us."