Wayne Rooney and Ryan Giggs are among five senior Manchester United players to have been ruled out of Wednesday's UEFA Champions League tie against CSKA Moscow.
United boss Sir Alex Ferguson had revealed that the influential duo had been doubtful for the game and they have not been included in the squad to travel to Russia.
Darren Fletcher, Park Ji-sung and Patrice Evra are also missing for United, who have made a 100 per cent start to Group B.
Giggs will not make the trip to the Russian capital after picking up a knock during the Red Devils' 2-1 win over Bolton Wanderers on Saturday when he played the full 90 minutes.
Rooney is out with the calf strain suffered on international duty with England and he sat out the Bolton game as a result of the problem.
He will also be sidelined for the game against CSKA Moscow, but Ferguson is optimistic the striker will be fit for Sunday's Premier League clash with arch-rivals Liverpool.
Evra was another player to collect a knock against Bolton and he was replaced by John O'Shea in the final 10 minutes at Old Trafford.
Fletcher and Park both missed the Bolton clash and are again unavailable as the 2008 winners look to edge a step closer to booking a place in the last 16 of the Champions League.
However, Nemanja Vidic, who missed out against the Trotters due to an ankle problem, has travelled with the squad, along with Dimitar Berbatov.