Sam Ricketts has been forced to pull out of Wales' upcoming 2010 World Cup qualifier against Finland.
John Toshack's side are set to tackle the Finns in their penultimate qualification contest on Saturday.
They will, however, be without Bolton defender Ricketts after he withdrew from the squad on Thursday with an ankle injury.
He has been unable to join in with full training this week and has been sent back to his club for treatment.
There is still a possibility he will have recovered in time for Wales' final fixture in their Group 4 campaign against Liechtenstein on Wednesday.
His absence for the weekend trip to Finland comes as a major blow to Toshack as he has already seen Jack Collison, Danny Gabbidon, Joe Ledley and Simon Davies ruled out.