Wales will be without West Ham defender Danny Gabbidon for their forthcoming World Cup qualifiers against Finland and Liechtenstein.
The Hammers centre-back has been unable to train for the past fortnight due to a calf injury and has failed to shake off the complaint in time for the international double-header.
It is a bitter blow for Gabbidon, who has been easing himself back to top-level action this season after a torrid two years on the sidelines with persistent injuries.
Gabbidon made his Wales comeback against Montenegro in August and also figured against Russia last month, but he is now out of the Finland clash in Helsinki on Saturday and next Wednesday's final qualifier in Liechtenstein.
Wales boss John Toshack has other injury concerns and will make a decision on Wednesday over the fitness of Cardiff midfielder Joe Ledley.
Ledley is suffering from a pelvic injury and had a scan on Tuesday to assess the problem. Ledley will now refer to a specialist, with the likelihood that he will also miss the Group 4 qualifiers.
Skipper Craig Bellamy reported to the squad's team hotel on Tuesday evening and is fit to travel, despite worries that he had picked up a knee problem on Monday after scoring in Manchester City's 1-1 draw at Aston Villa.