Patrick Vieira, Marco Materazzi and Walter Samuel have been left out of Inter Milan's squad to face Manchester United.
Argentine defender Samuel is missing after picking up a calf injury over the weekend.
Former Arsenal ace Vieira is only recently back from a long-term lay-off and Jose Mourinho has opted to leave him out.
Italian international Materazzi trained with his team-mates on Monday, but he is still struggling with a thigh injury.
Young defender Davide Santon could start in the absence of Materazzi and Samuel, while Sulley Muntari and Esteban Cambiasso are expected to start in central midfield.