Roda JC stunned Eredivisie leaders PSV Eindhoven with a 4-2 victory at the Philips Stadion.
PSV began the day with only one defeat from their opening 13 league matches, although they are now in danger of losing top spot to Ajax or Feyenoord.
The visitors found themselves in firm control of the game at half-time thanks to goals from Davy de Fauw and Marcel Meeuwis.
PSV had only conceded seven goals all season, although that record went out of the window in the second half.
Andres Oper made it 3-0 before Anouar Hadouir bagged a fourth in the 64th minute leaving the home fans stunned.
PSV did fight back late on, but an own goal by Jan Paul Saeijs and a Danny Koevermans goal only restored a little pride.