Last Updated at 9:58 pm, April 30th 2012
A huge cheer rings out around the Etihad Stadium as the final whistle goes, with City winning 1-0 to return to the top of the Premier League on goal difference.
Roberto Mancini makes his final change of the night to bring on James Milner for Samir Nasri.
United make their third and final change, with Ashley Young replacing the ineffective Nani.
Micah Richards is brought on in place of David Silva to further shore things up for Man City in the closing stages.
Michael Carrick fouls Gareth Barry right next to the managers' dugout and is shown a yellow card. Sir Alex Ferguson is not interested in speaking to Roberto Mancini on this occasion.
It was something of a surprise that Antonio Valencia did not start but he is on now, replacing surprise Paul Scholes for the closing stages.
Nigel de Jong goes in clumsily on Danny Welbeck and is shown a yellow card, but the real action comes on the touchline as Sir Alex Ferguson and Roberto Mancini almost square up to each other, only to be kept apart by officials.
Phil Jones becomes the first United player to be cautioned following a wild challenge on Gareth Barry in midfield.
Carlos Tevez will not score against his former club tonight as he is replaced by midfield enforcer Nigel de Jong. Quite a surprising decision to withdraw Tevez, but De Jong will add steel to the City midfield.
Sir Alex Ferguson decides it is time to make his first change and brings on Danny Welbeck for Park Ji-sung to give Wayne Rooney some more support up front.
Yaya Toure is booked for dissent after disagreeing with Andre Marriner's decision to give United a free-kick for a foul on Ryan Giggs.
The half-time whistle goes and City walk off to a standing ovation. They have dominated this match without creating too many chances, but Kompany struck at a crucial time just before the interval and the onus is now on United to respond.
GOAL David Silva delivers the corner and Vincent Kompany climbs highest to beat Chris Smalling in the air and power a header past David de Gea. The crowd erupts and that goal is fully deserved for City.
Referee Andre Marriner plays the advantage following a foul on Wayne Rooney by Vincent Kompany in midfield but Ryan Giggs' cross is intercepted by Joleon Lescott. Marriner returns to the scene of the crime to show Kompany a yellow card.
Manchester City are at 11/10 with Sky Bet and Manchester United are 12/5, with a draw 5/2. You can get odds of 11/1 that David Silva will be the first goalscorer, while Wayne Rooney is at 6/1.
"Hey, I'm Ayus Praharaj from Bhubaneswar, India. I'm going for a convincing 1-3 win for Manchester United with Rooney scoring a brace, and Nani also getting on the scoresheet! Go Uniteeedddddd!!!"
Angus in Edinburgh, aged nine, writes: "Well its gonna be a late night but good action. I'm in my City pjs so I think it will have 3 reds and 5 yellows. Wazza with a hat-trick and Tevy with 2 and that to be the final score. Come on the City."
"Hi it's Josh, I am a united fan and i think that people have got to be realistic in what they say. I believe it will be a very different defensive performance by both teams and one goal will decide it. I think that with United's current run of high goalscoring matches that United will barely come on top early in the second half with Paul Scholes to score from range. 1-0 to United."
Scot in Ft Lauderdale: "Sir Alex has certainly loaded his team with experience. The only familiar name missing from this line up is Captain Mainwaring!"
"Hi, David a Walsall fan from Walsall. Would love to see Manchester City to win tonight and throw the title chase straight to the wire, would love a new name on the trophy, always liked City ever since they were promoted with The Saddlers back in 1998/99 - Weird to see them challenging for the title while Walsall are battling against relegation to League 2. I predict 1-0 to City with a Carlos Tevez winner in the last 5 minutes."
Chris Dunkerley says: "That United team is a disgrace. How can they possibly compete. They do not deserve to win this match let alone the league. City to win 3-1."
Jim in Taiwan says: "Late night but hope it's going to be worth it.I'm a Leeds fan so obviously hoping for a City win. I predict 4 red cards..loads of gum chewing."
Harry says: "So excited yet anxious about this game can't wait for kick-off. As a United fan I want United to win I think the final score will be 4-1 to United! Come on you Reds title N0.20 is on the way!"
Qasid in Bromley writes: "I'm a Man Utd fan and I know that this will be an incredibly close match with both teams trying to go for the win. Aguero and Tevez to score in the first half before Utd produce a fight-back with Rooney to score before 60 mins and let's say Hernandez to level the scoreline in stoppage time. Oh and De Gea to make a penalty save somewhere along the way."
"Hi, I'm Harry from Newbury, this is going to be one hell of a game, I think Fergie has the edge here, but this all depends on his selection, Man city have been riding their luck all season and certainly have a fear factor against most clubs in the Premiership, but these kind of games really do suit Utd and they will overcome I'm sure, City still need a point to prove and both sides have a defence that is leakable, with goalscorers wanting to stamp their mark, so goals to be had tonight so I'm going with 3-2 maybe 4-2 utd, there will be goals there usually is......."
John Bagust in Prague says: "United will not lose tonight.They have the experience to handle City at this moment in the title race. 0-1 to Utd with a goal from Rooney. Shame tomorrow is a day off here in Prague - would love to see some of my City colleagues after we win!"
Arthur Albiston writes: "I feel Sir Alex has a lot more options than Mancini - you could probably pick most of the City lineup but Fergie will keep you guessing. I would be happy with a point but have a feeling United will break City hearts (or Hart) with a late winner - 2-1 United."
Spurs fan Stu says: "Evening Lewis, hoping for an exciting game for the neutral tonight..! I'm going for 3-2 to Utd, Rooney to get at least 2. And 3-2 at 28/1 not a bad shout"
Gabriel Sutton is the first to get in touch, saying: "Dead excited about tonight's game, even as a neutral Birmingham city fan! Gutted I'm out playing table tennis tonight but hopefully I can catch the highlights later on. Whilst I can't wait for the game, I think the winner will definitely win the title, there could be an element of nerves and anti-climax about it. I could see a 0-0 draw." Tough choice Gabriel, a night of table tennis or the Manchester derby.
LIVE and exclusive on Sky Sports
Barclays Premier League
|12||West Bromwich Albion||1||1|
|16||Queens Park Rangers||1||0|
|18||West Ham United||1||0|