Cadel Evans completed a strong week of racing after sealing overall victory at the Giro del Trentino.
With a sizeable lead heading into the deciding stage the Australian (BMC Racing) was content to cover the moves of his rivals on the final summit finish, coming home fifth behind the day's solo victor.
Spaniard Mikel Landa (Astana) overhauled the attack of Louis Meintjes (MTN Qhubeka) in the steep final kilometres to claim the stage victory on the final day.
Crossing the line with a margin of 10 seconds over the young South African, Landa pushed clear in the closing stages on the famous snow-capped Monte Bondone climb.
Sir Bradley Wiggins (Team Sky) had been part of the lead shake-up as he looked to hone his form ahead of a trip to the Tour of California.
The Brit immediately went on the offensive as the race hit the final climb and made his way into an elite front group containing Evans and nearest rival Domenico Pozzovivo (AG2R-La Mondiale).
Wiggins eventually faded and finished back in the pack following a stint on the front, while Pozzovivo and Prezemyslaw Niemiec (Lampre-Merida) made sure of their podium positions, 50 seconds and 1:01 respectively behind Evans.
The 175km jaunt from Val Daone was not for the faint hearted with three significant climbs leading up to the hors-categorie finale of Monte Bondone.
The final day provided one last chance for riders to bag a stage win and the race re-shuffled itself numerous times in the early going.
Diego Rosa (Androni Giocattoli) was the only rider from the original three-man break to remain out front and the Italian was eventually joined by a new wave of 11 attackers including Team Sky's Philip Deignan.
In the build-up to the climb Astana arrived at the head of affairs and for the second day in succession the break was caught as the final ascent began.
The contenders then took it in turns to up the pace, with Wiggins hitting the front with 13km to go as the favourites looked at one another.