Captain Michael Clarke has been forced to pull out of Australia's one-day tour of India because of his back injury.
The news will give Australia renewed cause for concern ahead of the forthcoming Ashes series with England.
Clarke's back injury caused him problems all the way through the summer tour of England.
Australia's team physiotherapist Alex Kountouris said: "Michael Clarke has a longstanding low back injury that requires ongoing management.
"During the recent England ODI series his injury flared up again and has been slow to improve with his regular treatment regime.
"Michael will therefore not be available to play the upcoming India ODI series and will require a more extensive rehabilitation period before returning to competitive cricket."
Australia will play a seven-game series in India from October 11. They will be coached by Steve Rixon while Darren Lehmann is rested.
South Australia's Callum Ferguson has been called up to replace Clarke in the squad.