Durham have returned the rights to two of their England internationals including the plum fixture against Australia in 2015.
The county has opted out of the chance to host that match and a Twenty20 international against India next summer as part of their long-term business plan.
But this does not mark a move away from Emirates Durham ICG, as the England and Wales Cricket Board said in a statement that the county would be guaranteed international cricket at Chester-le-Street until 2016.
The venue will stage an Ashes Test for the first time this summer, following that with limited overs matches against Sri Lanka (2014) and New Zealand (2015) before Sri Lanka return for a Test in 2016.
ECB chief executive David Collier said: "Today's announcement is in line with Durham's long-term business plan and means that the club will host an optimal number of major matches over the four-year period whilst allowing the north-east region to continue to benefit from regular international cricket."