Australia batsman Steven Smith has flown home from the tour of England because of injury.
Smith suffered a "very minor" quad strain in a training session and will take no further part in the limited overs series.
CA said that following Smith's involvement in the Ashes, and the preceding Australia A tour, a decision had been made to rest him from the upcoming limited-overs matches.
"Smith sustained a very minor left quad strain at training and after a demanding Ashes series the national selection panel (NSP) has decided it is best for him to return to Australia," a statement read.
"The NSP has advised that no replacement player will be added to the squad."
Australia won the first NatWest Twenty20 international by 39 runs at the Ageas Bowl on Thursday night.
That series concludes on Saturday in Chester-le-Street before Australia play Scotland in a one-off one-day international and England in a five-game series.