Six wickets for Chris Rushworth and a century by Scott Borthwick put Durham in a position of total command on the second day of their County Championship match against Derbyshire at Chester-le-Street.
After dismissing Division One's bottom club for 113, Durham reached 208-2 in their second innings to lead by 348.
Keaton Jennings made his second fifty of the match and remained unbeaten on 65 after sharing a stand of 168 with Borthwick.
Resuming on 15-1, the visitors never recovered from losing lost two wickets in the day's first eight balls.
The Durham seamers produced some excellent swing bowling in the baking heat and the only lengthy resistance came from Shivnarine Chanderpaul, who batted for 103 minutes for 14.
Rushworth swung one in to take out Richard Johnson's off stump in the first over and went on to finish 6-64. He is the one nominated to stand down if Graham Onions is not required by England tomorrow.
Wayne Madsen tried to turn Callum Thorp's second ball of the day to leg and gave the first of four catches to wicketkeeper Phil Mustard.
Thorp also had Dan Redfern caught at first slip in recording figures of 11-5-11-2, then Mark Wood struck in his second over when Tom Poynton edged a drive.
Ben Stokes troubled Chanderpaul more than anyone, but it was Rushworth who removed him with the third ball of his second spell. The West Indian made a very late decision to play at it and edged to Mustard.
Two balls later Jon Clare wafted loosely to be caught at gully, completing Rushworth's second five-wicket haul of the season.
Derbyshire were 81-8 at lunch, needing 23 to avoid the follow-on, and Rushworth had 5-39 at that point. He came under fire for two overs before taking the final wicket when he bowled Mark Footitt for 16.
Mark Stoneman, captaining Durham in the absence of Paul Collingwood with a thumb injury, fell lbw to Tim Groenewald for 10 when shouldering arms.
But Derbyshire began to look demoralised as Borthwick raced to 50 off 48 balls, pulling powerfully as he took advantage of too many short balls.
He reached his 117-ball century with a six pulled over mid-wicket off left-arm spinner David Wainwright, but departed for a career-best 117 when he was lbw on the back foot to the off spin of Redfern.